Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes. (July 2022)

• Record Type: Journal Article
• Authors: Pholtaisong, Jatuphol; Chaiyaratana, Nachol; Aporntewan, Chatchawit; Mutirangura, Apiwat
• Is Part Of: Evolutionary bioinformatics online. Volume 18(2022)
• Publication Date: 2022-07
• Subjects: Short tandem repeats -- microsatellites -- mononucleotide repeats -- A-repeats -- housekeeping genes -- mammals -- vertebrates -- endotherms; Bioinformatics -- Periodicals; Evolutionary computation -- Periodicals; Genetic programming (Computer science) -- Periodicals; Computational Biology; Evolution, Molecular; Bioinformatics; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 576.8
• DOI: 10.1177/11769343221110656
• Languages: English
• ISSNs: 1176-9343

Abstract

Background: Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals: H. sapiens, M. musculus, and R. norvegicus . Principal Findings: We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes. Conclusions: Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.