Wenxiang 3.0: Evolutionary Visualization of α, π, and 3/10 Helices. (May 2022)

• Record Type: Journal Article
• Authors: Jungck, John R; Cebeci, Metehan
• Is Part Of: Evolutionary bioinformatics online. Volume 18(2022)
• Publication Date: 2022-05
• Subjects: Wenxiang diagrams -- α -- π -- and 3/10 helices -- evolutionary conservation; Bioinformatics -- Periodicals; Evolutionary computation -- Periodicals; Genetic programming (Computer science) -- Periodicals; Computational Biology; Evolution, Molecular; Bioinformatics; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 576.8
• DOI: 10.1177/11769343221101014
• Languages: English
• ISSNs: 1176-9343

Abstract

Wenxiang diagrams illustrate protein helices as spirals on a plane and thus have the advantage over helical wheels of being planar graphs. Wenxiang 3.0 extends the original version by adding 3 major features: (1) individual amino acid residues can be colored according to their evolutionary conservation in comparative multiple sequence alignments using CONSURF encoding; (2) α, π, and 3/10 helices can be illustrated by overlaying arcs representative of the pitches of these helices; and, (3) the physico-chemical properties of amino acids residues in the protein sequence can be re-presented by colored geometric shapes.