Drosophila Melanogaster Show a Threshold Effect in Response to Radiation. Issue 4 (1st October 2014)

• Record Type: Journal Article
• Authors: Antosh, Michael; Fox, David; Hasselbacher, Thomas; Lanou, Robert; Neretti, Nicola; Cooper, Leon N.
• Is Part Of: Dose-response. Volume 12:Issue 4(2014)
• Publication Date: 2014-10-01
• Subjects: low dose radiation -- gene expression -- Drosophila melanogaster -- threshold effect; Dose-response relationship (Biochemistry) -- Periodicals; Drugs -- Dose-response relationship -- Periodicals; Drugs -- Physiological effect -- Periodicals; Hormesis -- Periodicals; Dose-Response Relationship, Drug -- Periodicals; Dose-response relationship (Biochemistry); Drugs -- Dose-response relationship; Drugs -- Physiological effect; Periodicals; 571.634
• DOI: 10.2203/dose-response.13-047.Antosh
• Languages: English
• ISSNs: 1559-3258

Abstract

We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.