A 25 Immune-Related Gene Pair Signature Predicts Overall Survival in Cervical Cancer. (April 2022)

• Record Type: Journal Article
• Authors: Chen, Huaqiu; Xie, Huanyu; Wang, Pengyu; Yan, Shanquan; Zhang, Yuanyuan; Wang, Guangming
• Is Part Of: Cancer informatics. Volume 21(2022)
• Publication Date: 2022-04
• Subjects: Cervical cancer -- immune cell infiltration -- prognostic signature -- immune-related gene pairs -- overall survival -- prognosis -- prognostic signature; Bioinformatics -- Periodicals; Biology -- Data processing -- Periodicals; Cancer -- Periodicals; Cancer -- Research -- Periodicals; Computational biology -- Periodicals; 570.285
• DOI: 10.1177/11769351221090921
• Languages: English
• ISSNs: 1176-9351

Abstract

Mounting evidence suggests that the tumor microenvironment plays an important role in the occurrence and development of cancer, with immune system dysfunction being closely related to malignant cancers. We aimed to screen immune-related genes (IRGs) to generate an IRG pair (IRGP)-based prognostic signature for cervical cancer (CC). Datasets were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases and used as training and validation cohorts, respectively. Using the ImmPort database, IRGs in control and CC samples were compared, and differentially expressed genes were identified to construct an IRGP prognostic signature. Based on this analysis, 25 IRGPs were identified as important factors for the prognosis of CC. Univariate and multivariate Cox regression analyses further showed that the IRGP signature was an independent prognostic factor of overall survival. In summary, we successfully constructed an IRGP prognostic signature of CC, providing insights into immunotherapy for CC.