Insight into the role of multiple signaling pathways in regulating cancer stem cells of gynecologic cancers. (October 2022)

• Record Type: Journal Article
• Authors: Song, Yizuo; Pan, Shuya; Li, Kehan; Chen, Xin; Wang, Z. Peter; Zhu, Xueqiong
• Is Part Of: Seminars in cancer biology. Volume 85(2023)
• Page Start: 219
• Page End: 233
• Publication Date: 2022-10
• Subjects: ADAM a disintegrin and metalloprotease -- ALDH1 aldehyde dehydrogenase-1 -- AMPK adenosine 5'-monophosphate-activated protein kinase -- APC adenomatous polyposis coli -- ATRA all-trans retinoic acid -- BLPs bayberry leaf proanthocyanidins -- BMP4 bone morphogenetic protein 4 -- BPA bisphenol A -- CaMK2 calmodulin kinase II -- CA-MSCs carcinoma-associated mesenchymal stem cells -- CBF C-repeat binding factor -- CCL the C-C chemokine ligand -- Cdc42 cell division control protein 42 -- CK casein kinase -- CSC cancer stem cell -- CSL CBF1/Suppressor of Hairless/LAG1 -- DLL Delta-like ligand -- DHH Desert HH -- DUSP6 dual-specificity phosphatase 6 -- EMT epithelial-mesenchymal transition -- EpCAM epithelial cell adhesion molecule -- ERK extracellular-signal-regulated kinase -- FTS fused toes homolog -- FZD frizzled receptor -- GβL GTPase β-subunit like protein -- Gli glioma-associated oncogene homolog -- Gli2-A Gli2 in its activator form -- Gli2-R Gli2 in its receptor form -- GSK3β glycogen synthase kinase 3β -- HGSOC high-grade serous ovarian cancer -- HH hedgehog -- HIF-1α hypoxia-inducible factor 1α -- Id1 the inhibitor of DNA binding/differentiation 1 -- IDO1 indoleamine 2, 3-dioxygenase 1 -- IL interleukin -- HPVE6 human papillomavirus oncoproteins E6 -- IHH Indian HH -- IKK IκB kinase -- IKKβ the β-subunit of IKK complex -- I-SMAD inhibitory Smad -- JAG Jagged -- JAK Janus kinase -- JIP JNK-interacting protein -- JNK c-Jun N-terminal kinase -- KSR1/2 Kinase suppressor of Ras 1 or 2 -- LAG lymphocyte activation gene -- LATS large tumor suppressor -- LEF lymphoid-enhancer factor -- LGR leucine-rich repeated containing G protein-coupled receptor -- LIF leukemia-inhibitory factor -- LKB liver kinase B -- LRP low-density lipoprotein-related protein -- MAPK mitogen-activated protein kinase -- MAP2K MAPK kinase -- MAP3K MAPK kinase-kinase -- MeSH medical subject heading -- MMP matrix metalloproteinase -- MP1 MEK partner 1 -- MOB1 MOB kinase activator 1 -- mTOR mammalian TOR -- mTORC mTOR complex -- MST mammalian STE20-like protein kinase -- MYPT1 myosin phosphatase target subunit 1 -- NAG-1 NSAID-activated gene 1 -- NF-κB the nuclear factor kappa B -- NICD Notch intracellular domain -- NIK NF-κB-inducing kinase -- NQC nano particle of quinacrine -- PCBs polychlorinated biphenyls -- PCP planar cell polarity -- PDGF the platelet-derived growth factor -- PDX patient-derived xenograft -- PI3K phosphoinositide 3-kinase -- PKC the protein kinase C -- PPARγ peroxisome proliferator-activated receptor γ -- PRR Proline-rich protein -- PTCH Patched -- RAC Ras-related C3 botulinum toxin substrate -- RhoA Ras homolog gene family member A -- RNPC1 RNA-binding region-containing protein 1 -- ROR RTK-like orphan receptor -- R-SMAD receptor-activated Smad -- RTK receptor-like tyrosine kinase -- SAPK stress-activated protein kinase -- SAV Salvador homologue 1 -- SC stem cell -- SHH Sonic HH -- SMO smoothened -- SIN SAPK-interacting protein -- sFRP4 secreted FZD-related protein 4 -- SIRT1 sirtuin-1 -- SMOC-2 SPARC-related modular calcium binding 2 -- STAT signal transducer and activator of transcription -- TAB1 TAK1-binding protein -- TAK1 TGF-β-activated kinase 1 -- TAZ transcriptional co-activator with PDZ-binding motif -- TCF T-cell factor -- TEAD transcriptional factors TEA domain family member -- TF3 Theaflavin-3, 3'-digallate -- TG2 tissue transglutaminase -- TGF-β the tumor growth factor-β -- TGFR TGF-β receptor -- Th17 T-helper -- TIMP-4 tissue inhibitor of metalloproteinase-4 -- TNF-α tumor necrosis factor alpha -- TOR target of rapamycin -- TSC tuberous sclerosis complex subunit -- YAP Yes-associated protein; Pathways -- Cancer stem cells -- Gynecologic cancers -- Treatments -- Ovarian cancer; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2021.06.001
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Mounting evidence has demonstrated that a myriad of developmental signaling pathways, such as the Wnt, Notch, Hedgehog and Hippo, are frequently deregulated and play a critical role in regulating cancer stem cell (CSC) activity in human cancers, including gynecologic malignancies. In this review article, we describe an overview of various signaling pathways in human cancers. We further discuss the developmental roles how these pathways regulate CSCs from experimental evidences in gynecologic cancers. Moreover, we mention several compounds targeting CSCs in gynecologic cancers to enhance the treatment outcomes. Therefore, these signaling pathways might be the potential targets for developing targeted therapy in gynecologic cancers.