A case of neonatal pemphigus vulgaris with co‐existing BP180 autoantibodies. Issue 1 (27th November 2019)

• Record Type: Journal Article
• Authors: Fenner, Justine; Min, Michelle S.; Liu, Stephanie; Silverberg, Nanette
• Is Part Of: Pediatric dermatology. Volume 37:Issue 1(2020)
• Page Start: 241
• Page End: 243
• Publication Date: 2019-11-27
• Subjects: bullous disease‐immunologic -- neonatal; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.14059
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: A male neonate was born with blisters on the trunk to a 37‐year‐old primigravid woman with a past medical history of recurrent, painful, topical steroid‐responsive oral blisters. The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris. Interestingly, both neonate and mother also had elevated levels of BP180 antibodies, classically seen in bullous pemphigoid. This case is unique in that it portrays neonatal pemphigus, an already rare condition, complicated by the presence of BP180 antibodies.