Oxidative cyanation of tertiary amines for facile synthesis of tetrahydroisoquinolines with quaternary centers. (9th November 2022)

• Record Type: Journal Article
• Authors: Ji, Yue; Zhang, Xue; Wu, Ya; Dang, Ze-Lin; Han, Wei-Wei; Wang, Si-Chang; Dong, San-Bao; Zhang, Qun-Zheng
• Is Part Of: Tetrahedron letters. Volume 110(2022)
• Publication Date: 2022-11-09
• Subjects: One-pot sequential process -- Oxidative dehydrogenation -- Cyanation -- Iminiums -- Tetrahydroisoquinolines with quaternary centers; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154175
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A facile and efficient synthesis of tetrahydroisoquinolines with quaternary centers has been successfully realized by orchestrating a sequential process consisted of N -bromosuccinimide oxidation and cyanation of tertiary amines. This compatible combination protocol enables one-pot synthesis of α-cyano tetrahydroisoquinolines containing a quaternary center with up to 99% yield.