Association between Copeptin and Metabolic Syndrome: A Systematic Review. (22nd October 2022)

• Record Type: Journal Article
• Authors: Rojas-Humpire, Ricardo; Soriano-Moreno, David R.; Galindo-Yllu, Brenda; Zafra-Tanaka, Jessica Hanae
• Other Names: Gumpricht Eric Academic Editor.
• Is Part Of: Journal of nutrition and metabolism. Volume 2022(2022)
• Publication Date: 2022-10-22
• Subjects: Nutrition -- Periodicals; Metabolism -- Periodicals; Diet in disease -- Periodicals; Metabolic Diseases; Metabolism; Nutrition Disorders; Nutritional Sciences; Diet in disease; Metabolism; Nutrition; Electronic journals; Periodicals; Periodicals; 363.8
• DOI: 10.1155/2022/5237903
• Languages: English
• ISSNs: 2090-0724

Abstract

Abstract : Background . Copeptin, a reliable marker for vasopressin release, has been associated with cardiometabolic diseases including metabolic syndrome (MetS). This systematic review aims to evaluate the association between copeptin and MetS. Methods . We searched in Pubmed, Scopus, EMBASE, and Web of Science databases until March 2021 and included observational studies (cohort studies, cross-sectional, and case-control) reporting the risk or prevalence of having MetS in patients with elevated copeptin levels compared to patients without elevated copeptin levels. The risk of bias was evaluated with the Newcastle-Ottawa Scale. Meta-analysis was not performed because of the heterogeneity of the copeptin cut-off values. Results . A total of 7 studies (5 cross-sectional, 1 case-control, and 1 cohort) were included comprising 11, 699 participants. Most of them were performed in the adult general population. Two cross-sectional and one case-control studies found a positive significant association between higher levels of copeptin and MetS. While three cross-sectional and one cohort studies found no association. The case-control study had several methodological limitations, most cross-sectional studies were methodologically adequate and the cohort study had no methodological issues. Conclusions . The association between copeptin and MetS is inconsistent. However, the arginine-vasopressin system impairment contributes to metabolic disorders, expressing plasma copeptin changes. Thus, more longitudinal studies are required to corroborate the association of copeptin and MetS.