A paradigm shift in retinal detachment repair: The concept of integrity. (November 2022)

• Record Type: Journal Article
• Authors: Muni, Rajeev H.; Lee, Wei Wei; Bansal, Aditya; Ramachandran, Arun; Hillier, Roxane J.
• Is Part Of: Progress in retinal and eye research. Volume 91(2022)
• Publication Date: 2022-11
• Subjects: Retinal detachment -- Integrity -- Pneumatic retinopexy -- Vitrectomy -- Retinal displacement -- Outer retinal folds -- Scleral buckle; Retina -- Periodicals; Retina -- Research -- Methodology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Periodicals; Eye Diseases -- Periodicals; Retina -- Periodicals; Rétine -- Périodiques; Rétine -- Recherche -- Méthodologie -- Périodiques; 617.7005
• DOI: 10.1016/j.preteyeres.2022.101079
• Languages: English
• ISSNs: 1350-9462

Abstract

Abstract: The management of rhegmatogenous retinal detachment has rapidly evolved over recent decades. A range of surgical techniques exist, all of which can achieve retinal reattachment in most cases. In recent years there have also been vast technical advances in retinal imaging that have introduced novel ways of visualizing and studying the retinal macro and microstructural anatomy following retinal detachment repair. Recent clinical trial data demonstrates that functional and patient-reported outcomes of retinal reattachment differ with surgical technique, accompanied by differences in anatomic biomarkers of retinal recovery or 'integrity'. We discuss recent insights into the physiology of retinal reattachment gleaned from multimodal imaging, which shed light on the pathophysiology of various post-operative anatomic abnormalities. The ideal scenario is to achieve retinal reattachment as soon as possible, without retinal displacement, outer retinal folds or discontinuity of the external limiting membrane, ellipsoid zone and interdigitation zone, with an intact foveal bulge. To this end, we present an in-depth contemporary account of current concepts and mechanisms involved during retinal reattachment surgery, supported by clinical data and mathematical modelling, awareness of which can help the vitreoretinal surgeon achieve better post-operative outcomes. In this review we substantiate the case for a paradigm shift in rhegmatogenous retinal detachment repair; beyond the emphasis on single-operation reattachment rates, and instead striving to maximize functional outcomes using minimally invasive techniques. This can only be achieved if vitreoretinal surgeons embrace all of the available techniques, with individualized selection of surgical approach and the resolute goal of optimizing the 'integrity' of retinal reattachment. Highlights: Functional outcomes vary with surgical technique for retinal detachment repair. Advances in imaging have enabled assessment of the integrity of retinal reattachment. Structural recovery of photoreceptors differs with variations in surgical technique. Risk of retinal displacement and outer retinal folds vary with surgical technique. Retinal pigment epithelium pump based procedures offer the best outcomes.