Effect of Bisphenol S on testicular tissue after low-dose lactation exposure. (15th December 2022)

• Record Type: Journal Article
• Authors: Fenclová, Tereza; Chemek, Marouane; Havránková, Jiřina; Kolinko, Yaroslav; Sudová, Vendula; Moravec, Jiří; Navrátilová, Jana; Klein, Pavel; Králíčková, Milena; Nevoral, Jan
• Is Part Of: Environmental pollution. Volume 315(2022)
• Publication Date: 2022-12-15
• Subjects: Bisphenol S -- Idiopathic infertility -- Lactation exposure -- Testicular tissue -- Blood-testis barrier -- Oxidative stress; BPs bisphenols -- BPA bisphenol A -- BPS bisphenol S -- BTB blood-testis barrier -- CX43 connexin 43 -- DAPI 4, 6-diamidino-2-phenylindole -- DES diethylstilbestrol -- DTT 1, 4-dithiothreitol -- GAPDH glyceraldehyde-3-phosphate dehydrogenase -- 8OHdG 8-hydroxydeoxyguanosin -- HSP90 heat shock protein 90 -- OCL11 occludin 11 -- PBS Phosphate buffered saline -- PND post-natal day -- PRDX6 peroxiredoxin 6 -- ROS reactive oxygen species -- TUNEL terminal deoxynucleotidyl transferase dUTP nick end labeling -- ZO zonula occludens 1 -- γH2AX phosphorylation of histone H2; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2022.120114
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Exposure to endocrine disruptors such as bisphenols, can lead to and be the explanation for idiopathic infertility. In our study, we assessed the effect of exposure to bisphenol S (BPS) via breast milk on the testicular tissue health of adult male mice. Lactating dams were exposed to BPS through drinking water (0.216 ng g bw/day and 21.6 ng g bw/day) from post-natal day 0–15. Although there was no significant difference in testicular histopathology between the control and experimental groups, we observed an increase in the number of tight and gap junctions in the blood-testis barrier (BTB) of adult mice after lactation BPS exposure. Moreover, there was an increase in oxidative stress markers in adult testicular tissue of mice exposed via breast milk. Our lactation model indicates that breast milk is a route of exposure to an endocrine disruptor that can be responsible for idiopathic male infertility through the damage of the BTB and weakening of oxidative stress resistance in adulthood. Highlights: Nursing exposure to BPS might be the cause of male idiopathic infertility. Nursing exposure to BPS decreases seminiferous epithelium height in adulthood. Volume of gap junctions in BTB increases by nursing exposure to BPS. Volume of tight junctions in BTB increases by nursing exposure to BPS. Nursing exposure to BPS increases oxidative stress in testicular tissue.