Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions. (November 2022)

• Record Type: Journal Article
• Authors: Bhalla, Sonalika; Mehan, Sidharth; Khan, Andleeb; Rehman, Muneeb U.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 142(2022)
• Publication Date: 2022-11
• Subjects: AAV Adeno-associated viruses -- Aꞵ Amyloid-ꞵ -- AchE Acetylcholinesterase -- AD Alzheimer's disease -- Akt Ak strain transforming -- AMP Adenosine MonoPhosphate -- Ang1 Angiopoietin-1 -- ASD Autism spectrum disorder -- ATP Adenosine Triphosphate -- BBB Blood Brain Barrier -- BDNF Brain-derived neurotrophic factor -- BMI Body mass index -- BTBR Black and Tan BRachyury -- cAMP Cyclic Adenosine MonoPhosphate -- cDNA Complementary DNA -- CHD8 Chromodomain-helicase-DNA-binding protein 8 -- CNS Central nervous system -- CSF Cerebrospinal Fluid -- CVAs cerebral vascular accidents -- DAT Dopamine transporter -- DSM Diagnostic and Statistical Manual of Mental Disorders -- eNOS Endothelial nitric oxide synthase -- EPAC Exchange Proteins directly Activated by cAMP -- ERK Extracellular signal-regulated protein kinase -- FC Functional connectivity -- FGF Fibroblast growth factor -- GABA Gamma-Aminobutyric acid -- GDP Guanosine Diphosphate -- GFAP Glial fibrillary acidic protein -- GHRH Growth-hormone-releasing hormone -- GIP Gastric inhibitory polypeptide -- GLP-1 Glucagon like peptide-1 -- GLP- 1 Glucagon like peptide-1 receptor -- GPCR G-protein coupled receptor -- Grb-2 Growth factor receptor-bound protein 2 -- GSK3-β Glycogen synthase kinase 3-beta -- GTP Guanosine triphosphate -- HbA1c Hemoglobin A1c -- HD Huntington's disease -- HI Hypoxic ischemia -- HPA Hypothalamic–pituitary–adrenal -- HTT Huntingtin -- i.g. intragastrically -- i.n. Intranasal -- i.p. Intraperitoneal -- IGF-1 Insulin like growth factor-1 -- IGF-1R Insulin like growth factor-1 receptor -- IL-6 Interleukin -- iNOS Inducible nitric oxide synthase -- IRS Insulin receptor sustrate -- LTP Long term potentiation -- MAPK mitogen-activated protein kinase -- MEK Mitogen-activated protein kinase kinase -- MI Myo-inositol -- mRNA messenger RNA -- mTOR mammalian Target of Rapamycin -- NAAG N-acetylglutamate -- NAC N-acetyl cysteine -- Nf-1 Neurofibromatosis 1 -- PD Parkinson's disease -- PI3k 3-Phosphoinositide-dependent kinase 1 -- PIP3 Phosphatidylinositol (3, 4, 5)-trisphosphate -- PKA protein kinase A -- PKB protein kinase B -- Ps9 Pseudogene 9 -- Raf Rapidly Accelerated Fibrosarcoma -- Ras Rat sarcoma -- REM Rapid eye movement -- ROS reactive oxygen species -- RTT Rett syndrome -- s.c. Subcutaneous -- SCI spinal cord compression injury -- Ser Serine -- SH2 Src homology 2 -- Shc Src homology 2 domain containing transforming protein -- SOS Son of Sevenless -- TBI Traumatic brain injury -- TGF-ꞵ Transforming growth factor -- Thr Threonine -- VEGF Vascular endothelial growth factor -- VGCCs Voltage gated calcium channels; Neurological dysfunctions -- Neurodegeneration -- IGF-1 -- GLP-1 -- Neuroprotection; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.104896
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous incretin hormone that regulates blood glucose levels and fatty acid oxidation in the brain. GLP-1 also exhibits similar functions and growth factor-like properties to IGF-1, which is likely how it exerts its neuroprotective effects. Recent preclinical and clinical evidence indicate that IGF-1 and GLP-1, apart from regulating growth and development, prevent neuronal death mediated by amyloidogenesis, cerebral glucose deprivation, neuroinflammation and apoptosis through modulation of PI3/Akt kinase, mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK/ERK). IGF-1 resistance and GLP-1 deficiency impair protective cellular signaling mechanisms, contributing to the progression of neurodegenerative diseases. Over the past decades, IGF-1 and GLP-1 have emerged as an essential component of the neuronal system and as potential therapeutic targets for several neurodegenerative and neuropsychiatric dysfunctions. There is substantial evidence that IGF-1 and GLP-1 analogues penetrate the blood-brain barrier (BBB) and exhibit neuroprotective functions, including synaptic formation, neuronal plasticity, protein synthesis, and autophagy. Conclusively, this review represents the therapeutic potential of IGF-1 and GLP-1 signaling target activators in ameliorating neurological disorders. Graphical Abstract: ga1 Highlights: IGF-1 and GLP-1 signaling promotes neuronal cell proliferation, growth and CNS development. Dysregulation of IGF-1 and GLP-1 involves in the progression of neurodegenerative and neuropsychiatric disorders. IGF-1 and GLP-1 downregulation is associated with amyloidogenesis, cerebral glucose deprivation, neuroinflammation and apoptosis. Potential IGF-1 and GLP-1 activators exhibit neuroprotective effects in various neurological dysfunctions.