Non-nutritive bioactive components in maternal milk and offspring development: a scoping review. (7th December 2022)

• Record Type: Journal Article
• Authors: Eisha, Shafinaz; Joarder, Ishraq; Wijenayake, Sanoji; McGowan, Patrick O.
• Is Part Of: Journal of developmental origins of health and disease. Volume 13:Number 6(2022)
• Page Start: 665
• Page End: 673
• Publication Date: 2022-12-07
• Subjects: Mammalian milk -- non-nutritive bioactive components of milk -- maternal factors -- offspring outcomes; Developmental biology -- Periodicals; Embryology, Human -- Periodicals; Disease susceptibility -- Periodicals; Prenatal influences -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; 612.64
• DOI: 10.1017/S2040174422000149
• Languages: English
• ISSNs: 2040-1744

Abstract

Abstract: Lactation is a critical time in mammalian development, where maternal factors shape offspring outcomes. In this scoping review, we discuss current literature concerning maternal factors that influence lactation biology and highlight important associations between changes in milk composition and offspring outcomes. Specifically, we explore maternal nutritional, psychosocial, and environmental exposures that influence non-nutritive bioactive components in milk and their links to offspring growth, development, metabolic, and behavioral outcomes. A comprehensive literature search was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR) guidelines. Predetermined eligibility criteria were used to analyze 3, 275 papers, and the final review included 40 primary research articles. Outcomes of this review identify maternal obesity to be a leading maternal factor influencing the non-nutritive bioactive composition of milk with notable links to offspring outcomes. Offspring growth and development are the most common modes of programming associated with changes in non-nutritive milk composition due to maternal factors in early life. In addition to discussing studies investigating these key associations, we also identify knowledge gaps in the current literature and suggest opportunities and considerations for future studies.