Perioperative management of malignant hyperthermia during general anesthesia: A report of two cases. Issue 10 (11th October 2022)

• Record Type: Journal Article
• Authors: Chi, Xiaowei; Xu, Yi; Liao, Hongbing; Chen, Tao; Li, Qiang; Fu, Qiang
• Is Part Of: Clinical case reports. Volume 10:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-11
• Subjects: dantrolene -- general anesthesia -- hypermetabolic crisis -- idiopathic scoliosis -- malignant hyperthermia -- tetralogy of Fallot; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.6426
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality. We present two seemingly typical cases of intraoperative MH development, with details on perioperative assessment and rescue. Postoperative genetic test showed mutations in the ryanodine receptor type 1 gene. Abstract : The presence of unexpected increases in PetCO2, HR, temperature, and exclusion of alternative causes shoule be sufficient to call the diagnosis of suspected MH and activate treatment for MH.