Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1. Issue 11 (22nd March 2022)

• Record Type: Journal Article
• Authors: Wang, Shen; Ma, Cong
• Other Names: Rizo Josep guestEditor.
• Is Part Of: FEBS open bio. Volume 12:Issue 11(2022)
• Page Start: 1939
• Page End: 1957
• Publication Date: 2022-03-22
• Subjects: Munc13 -- Munc18 -- SNARE complex assembly -- SNAREs -- synaptic exocytosis -- synaptic vesicle fusion; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.13394
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Neurotransmitter release by Ca 2+ ‐triggered synaptic vesicle exocytosis is essential for information transmission in the nervous system. The soluble N‐ethylmaleimide sensitive factor attachment protein receptors (SNAREs) syntaxin‐1, SNAP‐25, and synaptobrevin‐2 form the SNARE complex to bring synaptic vesicles and the plasma membranes together and to catalyze membrane fusion. Munc18‐1 and Munc13‐1 regulate synaptic vesicle priming via orchestrating neuronal SNARE complex assembly. In this review, we summarize recent advances toward the functions and molecular mechanisms of Munc18‐1 and Munc13‐1 in guiding neuronal SNARE complex assembly, and discuss the functional similarities and differences between Munc18‐1 and Munc13‐1 in neurons and their homologs in other intracellular membrane trafficking systems. Abstract : Munc18‐1 and Munc13‐1 regulate synaptic vesicle exocytosis via orchestrating neuronal SNARE complex (syntaxin‐1, SNAP‐25, and synaptobrevin‐2) assembly. In this review, we summarized recent advances towards the molecular mechanisms of Munc18‐1 and Munc13‐1 in guiding neuronal SNARE complex assembly and discussed the similarities and differences between Munc18‐1 and Munc13‐1 in neurons and their homologs in other intracellular membrane trafficking systems.