Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or "Unclear" Infection Imaging?. (20th September 2022)

• Record Type: Journal Article
• Authors: Gouws, Arno Christiaan; Kruger, Hendrik Gerhardus; Gheysens, Olivier; Zeevaart, Jan Rijn; Govender, Thavendran; Naicker, Tricia; Ebenhan, Thomas
• Is Part Of: Angewandte Chemie. Volume 134:Number 45(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-20
• Subjects: antibiotic-derived PET -- imaging of infection -- positron emission tomography -- radiolabeling -- radiotracers; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202204955
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are encouraging prospects to investigate new concepts, which could transform clinical care of complex infectious diseases. Researchers are aiming towards the extension beyond the routinely available radiopharmaceuticals and are looking for more effective tools that interact directly with causative pathogens. We reviewed and critically evaluated (challenges or pitfalls) antibiotic‐derived PET radiopharmaceutical development efforts aimed at infection imaging. We considered both radiotracer development for infection imaging and radio‐antibiotic PET imaging supplementing other tools for pharmacologic drug characterization; overall, a total of 20 original PET radiotracers derived from eleven approved antibiotics. Abstract : This Review provides summary and critical evaluation, including the challenges and pitfalls, of antibiotic‐derived positron emission tomographic radiopharmaceutical development efforts aimed at infection imaging either considered for radiotracer development for infection imaging or radio‐antibiotic PET imaging supplementing other tools for pharmacologic drug characterization.