Aminopyridinyl Tricosanamide Based Pseudoplastic and Thermoreversible Oleogels for pH‐Dependant in vitro Release of Metronidazole. Issue 40 (25th October 2022)

• Record Type: Journal Article
• Authors: Yadav, Eqvinshi; Sebastian, Sharol; Gupta, Manoj K.
• Is Part Of: ChemistrySelect. Volume 7:Issue 40(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-25
• Subjects: Oleogel -- Pseudoplastic -- Thermoreversible -- Topical Delivery -- pH-Responsive Drug Release; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202203014
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Oleogels are semi‐solid, thermo‐reversible and viscoelastic self‐assembled 3‐D networking structures in which edible oils are immobilized through physical interactions with oleogelators. Nowadays, oleogels have attracted the attention of researchers for its wide applications in pharmaceuticals, cosmetics and food industries. Therefore, we have prepared a new oleogel formulation for topical and transdermal applications of antimicrobial and antiseptic agent metronidazole with enhanced properties. Aminopyridinyl tricosanamide fatty acid amide oleogelator self‐assembled in edible oils, form stable/thermoreversible gel with good shear thinning and pseudoplasticity. Such oleogels may be excellent drug delivery vehicles for topical/transdermal applications due to their shear thinning and pseudoplastic behaviour. In addition, the pH of these gels fall in the range of skin pH which bodes well for potential applications on skin. These gels show a slow and controlled release of the drug in both acidic and slightly basic buffers, indicating long‐term antibacterial activity associated with such drug loaded oleogels. Abstract : Mustard oil (MO)‐ and olive oil (OO)‐based oleogel was prepared using 22DAP fatty acid amide gelator. Both MO and OO provide nourishment to the surface of the skin and these oils have antioxidant (MO), antifungal (OO), antimicrobial (OO) and cholesterol lowering properties (MO) adding to their additional benefits in drug delivery applications. Both oleogels show thermo‐reversible, pseudoplastic and shear thinning behaviour. This type of behavior enhancing their potential towards topical and transdermal drug delivery applications. Additionally, metronidazole composite oliogels have a very slow and controlled release of the drug, which makes them good for long term anti‐microbial activities.