Nanoarchitectonics of Indocyanine Green/Doxorubicin‐Loaded Hydroxyl Boron Nitride Nanosheets for Chemophotothermal Therapy. Issue 10 (25th October 2022)

• Record Type: Journal Article
• Authors: Liu, Ming; Sun, Chiyu; Wu, Shuangyan; Zhu, Mingchang; Zhang, Ying
• Is Part Of: ChemPlusChem. Volume 87:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-25
• Subjects: antitumor agents -- chemophotothermal therapy -- cooperative effects -- cytotoxicity -- drug delivery -- nanoparticles; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.202200277
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract: Biocompatible hydroxylated boron nitride nanosheets were effectively loaded with indocyanine green and doxorubicin using successive assembly. The indocyanine green/doxorubicin‐loaded hydroxyl boron nitride nanosheets (ICG/DOX@OH‐BNNS) integrated photothermal therapy and chemotherapy into a single nano vehicle. It had been confirmed that ICG/DOX@OH‐BNNS could produce reactive oxygen species and exhibit excellent photothermal effects and light‐triggered faster DOX release with NIR laser irradiation. On the other hand, the fluorescence of DOX in ICG/DOX@OH‐BNNS was also used for visualizing subcellular location. Compared with individual chemotherapy and photothermal therapy, the combined treatment of ICG/DOX@OH‐BNNS could synergistically induce the apoptosis and death of A549 cells and suppress S180 tumor growth in vivo. Abstract : Indocyanine green/doxorubicin‐loaded hydroxyl boron nitride nanosheets (ICG/DOX@OH‐BNNS) could produce ROS and provide an outstanding photothermal effect. Within NIR laser irradiation, IDB also causes a quicker release of DOX. Chemo‐photothermal therapy of ICG/DOX@OH‐BNNS could synergistically trigger the apoptosis and death of A549 cells and inhibit the growth of the S180 tumor in vivo, which has a significant potential for tumor therapy.