Measuring the margin distance in pulmonary wedge resection. Issue 7 (17th August 2022)

• Record Type: Journal Article
• Authors: Wolf, Andrea; Laskey, Daniel; Yip, Rowena; Beasley, Mary B.; Yankelevitz, David F.; Henschke, Claudia I.
• Is Part Of: Journal of surgical oncology. Volume 126:Issue 7(2022)
• Page Start: 1350
• Page End: 1358
• Publication Date: 2022-08-17
• Subjects: early stage NSCLC -- measurement variability -- recurrence -- tumor margin distance -- wedge resection; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.27053
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract: Background: Margin distance contributes to survival and recurrence during wedge resections for early‐stage non‐small cell lung cancer. The Initiative for Early Lung Cancer Research on Treatment sought to standardize a surgeon‐measured margin intraoperatively. Methods: Lung cancer patients who underwent wedge resection were reviewed. Margins were measured by the surgeon twice as per a standardized protocol. Intraobserver variability as well as surgeon–pathologist variability were compared. Results: Forty‐five patients underwent wedge resection. Same‐surgeon measurement analysis indicated good reliability with a small mean difference and narrow limit of agreement for the two measures. The median surgeon‐measured margin was 18.0 mm, median pathologist‐measured margin was 16.0 mm and the median difference between the surgeon–pathologist margin was −1.0 mm, ranging from −18.0 to 12.0 mm. Bland–Altman analysis for margin measurements demonstrated a mean difference of 0.65 mm. The limit of agreement for the two approaches were wide, with the difference lying between −16.25 and 14.96 mm. Conclusions: A novel protocol of surgeon‐measured margin was evaluated and compared with pathologist‐measured margin. High intraobserver agreement for repeat surgeon measurements yet low‐to‐moderate correlation or directionality between surgeon and pathologic measurements were found. Discussion: A standardized protocol may reduce variability in pathologic assessment. These findings have critical implications considering the impact of margin distance on outcomes.