Synthesis and Performance Testing of a BODIPY Fluorescent Probe for the Detection of Doxycycline Residues in Water Environment. Issue 40 (25th October 2022)

• Record Type: Journal Article
• Authors: Ding, Lingzhi; Guo, Qing; Sun, Xiaolong; Hu, Gaowei; Hu, Jiahuan; Fan, Shunwu; Fu, Yongqian
• Is Part Of: ChemistrySelect. Volume 7:Issue 40(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-25
• Subjects: BODIPY -- fluorescent probes -- fluorescence spectroscopy -- pollution; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202203410
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Doxycycline (DOX) has been used extensively in the control of animal diseases, which leads to its large‐scale accumulation in water and causes serious pollution problems. In this study, a BODIPY‐based fluorescent probe named DOX‐BOD was synthesized by a one‐pot method. The qualitative and quantitative detection of DOX was achieved by the specific response effect of DOX‐BOD on DOX. DOX‐BOD showed excellent performance and its fluorescence intensity decreased with the increase in DOX concentration. Besides, the detection limit was as low as 0.91 μM. The DOX detection method based on BODIPY fluorescent probe has good reproducibility and stability, and can be used for rapid and high‐sensitivity detection of DOX residues in the water environment, which is of great significance for environmental monitoring. Abstract : A green fluorescent probe (DOX‐BOD) based on BODIPY was designed and synthesized. The ‐COOH group of DOX‐BOD will combine with the ‐OH group and ‐NH2 group of doxycycline to form hydrogen bonds, resulting in the fluorescence quenching of DOX‐BOD, and the quenching mechanism is dynamic quenching. The qualitative and quantitative detection of residual doxycycline in the water environment can be achieved by the fluorescence change of DOX‐BOD.