Research progress in the establishment of pancreatic cancer models and preclinical applications. Issue 3 (5th October 2022)

• Record Type: Journal Article
• Authors: Wu, Weizheng; Wen, Kunming; Zhong, Yuxin
• Is Part Of: Cancer innovation. Volume 1:Issue 3(2022)
• Page Start: 207
• Page End: 219
• Publication Date: 2022-10-05
• Subjects: genetic engineering -- heterotopic -- model -- orthotopic -- pancreatic cancer -- pancreatic ductal adenocarcinoma; Cancer -- Research -- Periodicals; Oncology -- Periodicals; Cancer -- Treatment -- Technological innovations; Cancer -- Diagnosis -- Technological innovations; Cancer -- Research; Cancer -- Treatment -- Technological innovations; Oncology; Periodicals; 616.994
• DOI: 10.1002/cai2.31
• Languages: English
• ISSNs: 2770-9183

Abstract

Abstract: Pancreatic cancer (PC) is a highly malignant tumor in the digestive system. The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes, among which the mutation rate of the KRAS gene is as high as 90%. Currently, PC has limited treatment options, low therapeutic effects, and poor prognosis. Thus, more effective methods to combat PC are urgently needed. Some models that can more accurately reflect the biological behaviors and genomic characteristics of PC, such as its morphology, pathology, proliferation, and invasion, are being continuously developed. These include genetic engineering models, orthotopic xenograft models, and heterotopic xenograft models. Using these PC models, scientists have further verified promising drugs and potential therapeutic targets for PC treatment. This is of great significance for limiting the progression of PC with clinical intervention, improving patient outcomes, and improving survival rates. Abstract : In recent years, some novel mouse pancreatic cancer models (including orthotopic and heterotopic models) which can show more realistic features of human pancreatic cancer and contribute to the validation of drugs and targets with therapeutic potential in pancreatic cancer have been established by using different technical means. This is of great significance for clinically improving the prognosis of pancreatic cancer patients.