Cover Picture: Enantioselective [2+2] Cycloaddition of Allenyl Imide with Mono‐ or Disubstituted Alkenes (Angew. Chem. Int. Ed. 44/2022). Issue 44 (25th October 2022)

• Record Type: Journal Article
• Authors: Xiao, Wanlong; Ning, Lichao; Xin, Shuang; Dong, Shunxi; Liu, Xiaohua; Feng, Xiaoming
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 44(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-25
• Subjects: Alkenes -- Allenes -- Asymmetric Catalysis -- Axially Chiral Cyclobutenes -- [2+2] Cycloaddition; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202214306
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : A chiral Lewis acid catalysed asymmetric [2+2] cycloaddition reaction of allenyl imide and alkenes was developed by Xiaohua Liu, Xiaoming Feng et al. in their Research Article (e202211596 ). This protocol provided a series of axially chiral cyclobutenes in high yields with excellent enantioselectivities. A stepwise mechanism was proposed based on experimental studies and DFT calculations, and π–π stacking interactions were identified as crucial for the enantioselectivity.