Postpartum regression of human papillomavirus‐related vulvar cancer: A case report. Issue 11 (16th August 2022)

• Record Type: Journal Article
• Authors: Murakami, Mayu; Taniguchi, Shuichi; Murakami, Takeshi; Imamura, Hiroko; Marutsuka, Kousuke; Shimamoto, Tomihiro
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 48:Issue 11(2022)
• Page Start: 2982
• Page End: 2987
• Publication Date: 2022-08-16
• Subjects: histology -- human papillomavirus -- pregnancy -- squamous cell carcinoma -- vulvar cancer; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.15389
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: We report a case of a 23‐year‐old pregnant woman (gravida 2 para 0, pregnancy 33 weeks and 3 days) with a history of laser ablation for cervical intraepithelial neoplasia‐3 at 22 years. At initial visit, a 2 × 2 × 1‐cm elevated mass was found on right labia majora. Biopsy results revealed squamous cell carcinoma of right labia; immunostaining revealed p16 positivity. Patient was diagnosed with human papillomavirus‐related vulvar cancer. Selective cesarean section was performed at 36 weeks and 4 days of gestation. Postoperative histopathological diagnosis of squamous cell carcinoma, and 1.7‐mm deep infiltrations led to vulvar cancer stage IB diagnosis. Reduction operation was performed, and postoperative follow‐up of 1 year and 8 months revealed no recurrence. These results emphasize that small vulvar tumors during pregnancy should not be underestimated and histological examinations should be performed without hesitation. Careful observation and evaluation of tumors is necessary during pregnancy and after delivery because they may shrink postdelivery.