Prenylaromadendrane-type diterpenoids from the gum resin of Boswellia sacra flueck and their cytotoxic effects. Issue 21 (1st November 2022)

• Record Type: Journal Article
• Authors: Wang, Jia-Jia; Suo, Xin-Yue; Sun, Hao-Ran; Wang, Xue; Lin, Ming-Bao; Wang, Jin-Hua; Jiang, Jian-Dong; Ji, Teng-Fei
• Is Part Of: Natural product research. Volume 36:Issue 21(2022)
• Page Start: 5400
• Page End: 5406
• Publication Date: 2022-11-01
• Subjects: Boswellia sacra Flueck -- Burseraceae -- prenylaromadendranoids -- cytotoxicity -- nitric oxide inhibition activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1939331
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new prenylaromadendrane-type diterpenoids, and three known analogues, were isolated from the ethanol extract of the gum resin of B. sacra Flueck. The structures of the new compounds were elucidated using 1 D and 2 D NMR spectroscopic analyses, mass spectrometric data, circular dichroism spectra, and comparison with the other compounds in the literature. One diterpenoid represents the first example of an acetoxyl-substituted prenylaromadendranoid in frankincense. All compounds exhibited notable cytotoxicity against human malignant glioma (U87-MG) cell line, with inhibitory rates exceeding that of the positive control 5-fluorouracil. However, nitric oxide inhibition induced by lipopolysaccarides was not observed in primary mouse peritoneal macrophages. Graphical Abstract: UF0001