A new anti-proliferative compound from an endophytic fungus, Phoma sp. Issue 21 (1st November 2022)

• Record Type: Journal Article
• Authors: Ku, Hyeri; Baek, Ji-Yun; Kang, Ki Sung; Shim, Sang Hee
• Is Part Of: Natural product research. Volume 36:Issue 21(2022)
• Page Start: 5584
• Page End: 5590
• Publication Date: 2022-11-01
• Subjects: Phoma sp. -- endophyte -- macrooxazole -- structure elucidation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2022663
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new oxazole-type compound (1 ), named macrooxazole E, and three known macrooxazoles A-C (2 –4 ), were isolated from ethyl acetate (EtOAc) extracts of Phoma sp. JS0228 cultures, an endophytic fungus of Morus alba ( M. alba ). Structures of the isolated compounds were determined using spectroscopic methods, such as 1 D- and 2 D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Macrooxazole E (1 ) differed from macrooxazole C only in the presence of methyl carboxylate instead of free carboxylic acid. Macrooxazole C showed moderate anti-proliferative activities against human breast cancer (MCF-7) and prostate cancer (LNCaP) cell lines with IC50 values of 0.29 mM and 0.36 mM, respectively. This study presents the possibility of the endophytic fungus Phoma sp. JS0228 to produce new bioactive natural compounds. Graphical Abstract: UF0001