Two novel amide alkaloids from Portulaca oleracea L. and their anti-inflammatory activities. Issue 21 (1st November 2022)

• Record Type: Journal Article
• Authors: Lan, Xiujuan; Ying, Ziyue; Guo, Shengnan; Duan, Yang; Cui, Xinyu; Leng, Aijing; Ying, Xixiang
• Is Part Of: Natural product research. Volume 36:Issue 21(2022)
• Page Start: 5567
• Page End: 5574
• Publication Date: 2022-11-01
• Subjects: Portulaca oleracea L. -- amide alkaloids -- structure elucidation -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2021519
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In this article, two novel amide alkaloids were identified as ( E )-3-(4-hydroxy-3-methoxyphenyl)-1-(5-hydroxy-6-((3, 4, 5-trihydroxy-6-(hydroxymethyl)tetrahydro-2 H -pyran-2-yl)oxy)-1 H -indol-1-yl)prop-2-en-1-one (1 ) and ( E )-1-(5-hydroxy-6-((3, 4, 5-trihydroxy-6-(hydroxymethyl)tetrahydro-2 H -pyran-2-yl)oxy)-1 H -indol-1-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one (2 ), the two compounds were named oleraindole E and oleraindole F, respectively. The structures were elucidated using 1D and 2D NMR and HR-ESI-TOF-MS spectra. Additionally, the anti-inflammatory activities were evaluated on RAW264.7 cells induced by LPS, compounds 1 and 2 exhibited anti-inflammatory activities at 20 μM. Graphical Abstract: UF0001