Rare prenylated isoflavonoids from the young twigs of Millettia extensa and their cytotoxic activities. Issue 47 (24th October 2022)

• Record Type: Journal Article
• Authors: Cheenpracha, Sarot; Chokchaisiri, Ratchanaporn; Laphookhieo, Surat; Limtharakul, Thunwadee; Thepmalee, Chutamas
• Is Part Of: RSC advances. Volume 12:Issue 47(2022)
• Page Start: 30359
• Page End: 30364
• Publication Date: 2022-10-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra05950a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Three new isoflavonoids, millexatins N–P (1–3 ), along with seven known compounds (6–10 ), were isolated from the acetone extract of the young twigs of Millettia extensa . Abstract : Three new isoflavonoids, millexatins N–P (1–3 ), along with seven known compounds (6–10 ), were isolated from the acetone extract of the young twigs of Millettia extensa . The structures were characterized by NMR spectroscopic and mass spectrometric analyses. Millexatin N (1 ) is an unusual geminal diisoprenylated isoflavone with a modified ring A. Millexatin P (3 ) is an unusual isoflavone with a cyclohexyl substituent on ring B, which is extremely rare in nature. The isolated metabolites (1, 2, and 6–10 ) were evaluated for cytotoxicities against MDA-MB231, Huh-7, KKU-100 and normal human dermal fibroblast (NHDF) cell lines. Only compounds 1, 6 and 8 showed cytotoxicities against all cell lines with IC50 values ranging from 13.9 to 30.9 μM.