Biochemical characterization of a cyanobactin arginine-N-prenylase from the autumnalamide biosynthetic pathway. Issue 86 (4th October 2022) - Clemente, Claudia
Abstract : Biochemical characterization of the prenyltransferase (AutF) from the autumnalamide pathway shows it targets the nitrogen of the guanidinium moiety in arginine and homoarginine. Abstract : Cyanobactins are linear and cyclic post-translationally modified peptides. Here we show that the prenyl-d -Arg-containing autumnalamide A is a member of the cyanobactin family. Biochemical assays demonstrate that the AutF prenyltransferase targets the guanidinium moiety in arginine and homoarginine and is a useful tool for biotechnological applications.