Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study. (6th October 2022)

• Record Type: Journal Article
• Authors: Chandna, Arjun; Mahajan, Raman; Gautam, Priyanka; Mwandigha, Lazaro; Kumar, Pragya; Varghese, George M; Koshiaris, Constantinos; Lubell, Yoel; Burza, Sakib
• Is Part Of: Open forum infectious diseases. Volume 9:Number 10(2022)
• Publication Date: 2022-10-06
• Subjects: COVID-19 -- host biomarker -- prognosis; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac526
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)–1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.