Replication Stress Impairs Chromosome Segregation and Preimplantation Development in Human Embryos. Issue 11 (November 2022)

• Record Type: Journal Article
• Authors: Palmerola, Katherine L.; Amrane, Selma; De Los Angeles, Alejandro; Xu, Shuangyi; Wang, Ning; de Pinho, Joao; Zuccaro, Michael V.; Taglialatela, Angelo; Massey, Dashiell J.; Turocy, Jenna; Robles, Alex; Subbiah, Anisa; Prosser, Bob; Lobo, Rogerio; Ciccia, Alberto; Koren, Amnon; Baslan, Timour; Egli, Dieter
• Is Part Of: Obstetrical & gynecological survey. Volume 77:Issue 11(2022)
• Page Start: 660
• Page End: 661
• Publication Date: 2022-11
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/OGX.0000000000001098
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Cell 2022;185:2988.e20–3007.e20) Spontaneous DNA damage, such as double-strand breaks (DSBs), affects cell-cycle progression and contributes to embryo attrition. There is a strong correlation among mitotic cell-cycle progression, ploidy, the quality of the blastocyst formed, and successful implantation from in vitro fertilization.