Editors' Note: Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease. (30th August 2022)

• Record Type: Journal Article
• Authors: Lewis, Ariane; Galetta, Steven
• Editors: Galetta, Steven; Ganesh, Aravind; Lewis, Ariane; Siegler, James E.
• Is Part Of: Neurology. Volume 99:Number 9(2022)
• Page Start: 403
• Page End: 403
• Publication Date: 2022-08-30
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000201129
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : In "Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease, " Chen et al. reported that a reduction in fecal short-chain fatty acids (SCFAs) is associated with increased clinical severity of Parkinson disease (PD). Brenner commented that this may be attributed to the fact that a reduction in SCFAs can lead to increased growth of Escherichia coli, which produce curli fibers that can accelerate production of amyloids and subsequent action pathology related to alpha-synuclein. Lin et al. agreed that curli production may lead to alpha-synuclein aggregation and neuroinflammation, as seen in PD. The authors further concurred that the gut-brain relationship in PD may be related to SCFAs, curli-producing E. coli, functional amyloids, and alpha-synuclein.