Effect of topical povidone–iodine 10% plus levofloxacin 0.5% 1 hour before cataract surgery in eliminating perioperative conjunctival flora: randomized clinical trial. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Eslami, Jamshid; Rezaei, Roghayeh; Jamali, Hossein; Sedaghat, Ahad; Nowroozzadeh, Mohammad Hossein
• Is Part Of: Journal of cataract and refractive surgery. Volume 47:Issue 3(2021)
• Page Start: 340
• Page End: 344
• Publication Date: 2021-03
• Subjects: 617.7
• DOI: 10.1097/j.jcrs.0000000000000436
• Languages: English
• ISSNs: 0886-3350

Abstract

Abstract : A simple approach of adjuvant instillation of povidone–iodine and levofloxacin drops 1 hour before operation leads to higher rate of sterile conjunctiva at the time of surgery. Abstract : Purpose: To evaluate the effect of a single administration of topical povidone–iodine (PVI) 10% plus levofloxacin 0.5% at 1 hour before cataract surgery on perioperative elimination rate of conjunctival flora. Setting: Poostchi Ophthalmology Research Center, Shiraz, Iran. Design: Randomized controlled trial. Method: Patients who required cataract surgery were randomly assigned to 1 of 2 groups: intervention (administration of PVI 10% plus levofloxacin 0.5% at 1 hour preoperatively) or control. The patients in both groups received PVI just before the operation. Conjunctival cultures were obtained using thioglycollate broth at 4 timepoints: T1, before intervention; T2, before the second application of PVI; T3, 3 minutes after the second administration of PVI; and T4, just postoperatively. Results: The study comprised 142 patients. The comparative rates of positive cultures in the intervention vs control groups were as follows: T1 (70.4% vs 73.2%, P = .709); T2 (15.5% vs 71.8%, P < .001); T3 (7.0% vs 19.7%, P = .027); and T4 (5.6% vs 4.2%, P = .698). Coagulase-negative Staphylococci was the most common isolated microorganism. Conclusions: Results showed that a single adjuvant application of PVI 10% plus levofloxacin 0.5% eyedrops at 1 hour before operation leads to a further increase in the rate of sterile conjunctiva just preoperatively.