Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water. (October 2022)

• Record Type: Journal Article
• Authors: Jansen, Jeannette; Beyreuther, Elke; García-Calderón, Daniel; Karsch, Leonhard; Knoll, Jan; Pawelke, Jörg; Schürer, Michael; Seco, Joao
• Is Part Of: Radiotherapy and oncology. Volume 175(2022)
• Page Start: 193
• Page End: 196
• Publication Date: 2022-10
• Subjects: FLASH effect -- Oxygen depletion -- Radical reduction -- Pulse structure; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2022.08.024
• Languages: English
• ISSNs: 0167-8140

Abstract

Highlights: O2 depletion in water is affected by beam pulse patterns. Average dose rate has higher impact than pulse dose rate. Water results correlate with biological data on FLASH effect => radicals as cause for FLASH effect. Abstract: The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O2 content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.