Interactive Materials for Bidirectional Redox‐Based Communication. Issue 18 (31st March 2021)
- Record Type:
- Journal Article
- Title:
- Interactive Materials for Bidirectional Redox‐Based Communication. Issue 18 (31st March 2021)
- Main Title:
- Interactive Materials for Bidirectional Redox‐Based Communication
- Authors:
- Li, Jinyang
Wang, Sally P.
Zong, Guanghui
Kim, Eunkyoung
Tsao, Chen‐Yu
VanArsdale, Eric
Wang, Lai‐Xi
Bentley, William E.
Payne, Gregory F. - Abstract:
- Abstract: Emerging research indicates that biology routinely uses diffusible redox‐active molecules to mediate communication that can span biological systems (e.g., nervous and immune) and even kingdoms (e.g., a microbiome and its plant/animal host). This redox modality also provides new opportunities to create interactive materials that can communicate with living systems. Here, it is reported that the fabrication of a redox‐active hydrogel film can autonomously synthesize a H2 O2 signaling molecule for communication with a bacterial population. Specifically, a catechol‐conjugated/crosslinked 4‐armed thiolated poly(ethylene glycol) hydrogel film is electrochemically fabricated in which the added catechol moieties confer redox activity: the film can accept electrons from biological reductants (e.g., ascorbate) and donate electrons to O2 to generate H2 O2 . Electron‐transfer from an Escherichia coli culture poises this film to generate the H2 O2 signaling molecule that can induce bacterial gene expression from a redox‐responsive operon. Overall, this work demonstrates that catecholic materials can participate in redox‐based interactions that elicit specific biological responses, and also suggests the possibility that natural phenolics may be a ubiquitous biological example of interactive materials. Abstract : A redox‐active catechol‐based film can autonomously synthesize diffusible H2 O2 signals that enable interactive communication with biology. The reducing redox activitiesAbstract: Emerging research indicates that biology routinely uses diffusible redox‐active molecules to mediate communication that can span biological systems (e.g., nervous and immune) and even kingdoms (e.g., a microbiome and its plant/animal host). This redox modality also provides new opportunities to create interactive materials that can communicate with living systems. Here, it is reported that the fabrication of a redox‐active hydrogel film can autonomously synthesize a H2 O2 signaling molecule for communication with a bacterial population. Specifically, a catechol‐conjugated/crosslinked 4‐armed thiolated poly(ethylene glycol) hydrogel film is electrochemically fabricated in which the added catechol moieties confer redox activity: the film can accept electrons from biological reductants (e.g., ascorbate) and donate electrons to O2 to generate H2 O2 . Electron‐transfer from an Escherichia coli culture poises this film to generate the H2 O2 signaling molecule that can induce bacterial gene expression from a redox‐responsive operon. Overall, this work demonstrates that catecholic materials can participate in redox‐based interactions that elicit specific biological responses, and also suggests the possibility that natural phenolics may be a ubiquitous biological example of interactive materials. Abstract : A redox‐active catechol‐based film can autonomously synthesize diffusible H2 O2 signals that enable interactive communication with biology. The reducing redox activities of a bacterial culture provide the electrons that poise this film for subsequent electron‐donation to O2 to generate the H2 O2 signaling molecule that induces redox‐responsive gene expression. … (more)
- Is Part Of:
- Advanced materials. Volume 33:Issue 18(2021)
- Journal:
- Advanced materials
- Issue:
- Volume 33:Issue 18(2021)
- Issue Display:
- Volume 33, Issue 18 (2021)
- Year:
- 2021
- Volume:
- 33
- Issue:
- 18
- Issue Sort Value:
- 2021-0033-0018-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2021-03-31
- Subjects:
- catechols -- electro‐biofabrication -- extracellular electron transfer -- interactive materials -- redox signaling
Materials -- Periodicals
Chemical vapor deposition -- Periodicals
620.11 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4095 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/adma.202007758 ↗
- Languages:
- English
- ISSNs:
- 0935-9648
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0696.897800
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 24183.xml