Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy. Issue 18 (1st April 2021)

• Record Type: Journal Article
• Authors: Liang, Shuang; Xiao, Xiao; Bai, Lixin; Liu, Bin; Yuan, Meng; Ma, Ping'an; Pang, Maolin; Cheng, Ziyong; Lin, Jun
• Is Part Of: Advanced materials. Volume 33:Issue 18(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-04-01
• Subjects: chemodynamic therapy -- defects -- sonodynamic therapy -- Ti‐based metal–organic frameworks; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202100333
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, a defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect is simply constructed and used for enhanced SDT. Compared with the commonly used sonosensitizer TiO2, D‐MOF(Ti) results in a superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves the US‐triggered electron–hole separation. Meanwhile, due to the existence of Ti 3+ ions, D‐MOF(Ti) also exhibits a high level of Fenton‐like activity to enable chemodynamic therapy. Particularly, US as the excitation source of SDT can simultaneously enhance the Fenton‐like reaction to achieve remarkably synergistic outcomes for oncotherapy. More importantly, D‐MOF(Ti) can be degraded and metabolized out of the body after completion of its therapeutic functions without off‐target toxicity. Overall, this work identifies a novel Ti‐familial sonosensitizer harboring great potential for synergistic sonodynamic and chemodynamic cancer therapy. Abstract : A defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) is successfully constructed by simple hydrogenation and serves as a new generation of robust sonosensitizer for enhanced sonodynamic therapy. Moreover, it also exhibits a high level of Fenton‐like activity to amplify production of reactive oxygen species under ultrasound irradiation. Besides, the degradability of D‐MOF(Ti) is a bright spot for promoting its clinical transformation.