Analysis of the Clinical Efficacy of Azacytidine + Venetoclax in the Treatment of Elderly Patients with Relapsed Refractory Acute Myeloid Leukemia. (14th October 2022)

• Record Type: Journal Article
• Authors: Wang, Wei; Luo, Quanfang; Chen, Qinpin; Pang, Aiping; Fang, Kuiyan
• Other Names: Wu Xueliang Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2022(2022)
• Publication Date: 2022-10-14
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2022/8691835
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Objective . To explore the clinical efficacy of azacytidine + venetoclax in the treatment of elderly patients with relapsed refractory acute myeloid leukemia (AML). Method . The present study included 20 elderly patients with relapsed refractory AML from January 2019 to January 2021. These patients were randomized into treatment groups ( n = 10, azacytidine alone) and control groups ( n = 10, azacytidine + venetoclax) by a random number table. The differences in efficacy, adverse reactions, hematology parameters, and immune functions in elderly patients with relapsed refractory AML in two groups were analyzed. Results . The total efficiency for elderly patients with relapsed refractory AML was 90.00% and significantly higher than that in the control group (40.00%), P < 0.05 ; PLT and WBC after treatment in the treatment group were significantly higher than those in the control group, and Hb was significantly lower than in the control group, P < 0.05 ; CD4+, CD3+, and CD4+/CD8+ after treatment in both groups were significantly lower than those before treatment, P < 0.05 ; CD4+, CD3+, and CD4+/CD8+ after treatment were not significantly different between the two groups, P > 0.05 ; the incidences of adverse reactions were not significantly different between the two groups, P > 0.05 . Conclusion . Azacytidine + venetoclax in the treatment of elderly patients with relapsed refractory AML could improve efficacy and hematology parameters with high safety, which is of great significance.