An ultra-sensitive rifampicin electrochemical sensor based on Fe3O4 nanoparticles anchored Multiwalled Carbon nanotube modified glassy carbon electrode. (December 2022)

• Record Type: Journal Article
• Authors: Alizadeh, Marzie; Asrami, Padideh Naderi; Altuner, Elif Esra; Gulbagca, Fulya; Tiri, Rima Nour Elhouda; Aygun, Aysenur; Kaynak, İdris; Sen, Fatih; Cheraghi, Somaye
• Is Part Of: Chemosphere. Volume 309:Part 1(2022)
• Publication Date: 2022-12
• Subjects: Fe3O4 NPs -- MWCNT -- Rifampicin -- Sensor -- Tuberculosis drug; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.136566
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: This study aimed to guide future sensor studies against other pharmaceutical drugs by synthesizing Fe3 O4 NPs@MWCNT metallic nanoparticles (NPs). Side damage caused by excessive accumulation of tuberculosis drugs in the body can cause clots in the organs, and cause serious damage such as heart attack and respiratory failure, and threaten human life. Therefore, the development of sensors sensitive to various antibiotics in this study is important for human health. In this study, the sensitivity of Fe3 O4 NPs to tuberculosis drug (rifampicin) was evaluated by catalytic reaction using bare/GCE, MWCNT/GCE, and Fe3 O4 NPs@MWCNT/GCE electrodes. First of all, Fe3 O4 NPs were successfully synthesized for the study and MWCNT/GCE and Fe3 O4 NPs@MWCNT/GCE electrodes were formed with the modification of the MWCNT support material. It was observed that the Fe3 O4 NPs@MWCNT/GCE electrode gave the highest signal against the other electrodes. The morphological structure of Fe3 O4 NPs was determined by various characterization techniques such as Transmission Electron Microscopy (TEM), Fourier Transmission Infrared Spectroscopy (FTIR), ultraviolet–visible (UV–Vis), and X-ray differential (XRD) and the obtained NPs were used for sensor studies, and it was observed that the current intensity increased as the scanning speed of each electrode increased in CV and DPV measurements. The average size of Fe3 O4 NPs was found to be 7.32 ± 3.2 nm. Anodic current peaks occurred in the linear range of 2–25 μM. According to the results obtained from the measurements, the limit of detection (LOD) value was calculated as 0.64 μM limit of quantification (LOQ) 1.92 μM. Graphical abstract: Image 1 Highlights: An ultra-sensitive Rifampicin Electrochemical Sensor. Fe3 O4 Nanoparticles anchored Multiwalled Carbon nanotube based sensor (Fe3 O4 NPs@MWCNT) The detailed characterization of Fe3 O4 NPs@MWCNT.