An Assessment of Anticancer Activity (MCF-7) and Free Radicals Scavenging Potential of Ferula Asafoetida Synthesized AgNPs through In Vitro Analyses. (10th October 2022)

• Record Type: Journal Article
• Authors: Thanh, Nguyen Chi; Chinnathambi, Arunachalam; Alahmadi, Tahani Awad; Joshi, Deepika; Jhanani, G. K.; Haile, Adisu
• Other Names: Sonthalia Ankit Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2022(2022)
• Publication Date: 2022-10-10
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2022/6095005
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Nanomaterials are increasingly being used in pharmaceutical industry to treat a variety of disorders and diseases. Hence, the aim of this research was to evaluate their antioxidant and anticancer activity of presynthesized and characterized plant-based AgNPs against ferric, DPPH, H2 O2, and ABTS free radicals and MCF-7 cell line. Interestingly, the antioxidants assay results revealed that the increased concentration (100 μ g mL -1 ) of AgNPs has remarkable antioxidant ability on ferric (78.20%), DPPH (89.61%), H2 O2 (82.34%), and ABTS (67.95%) free radicals. These scavenging activities were almost close to the free radicals scavenging ability of vitamin C (ascorbic acid). Similarly, test AgNPs showed considerable cytotoxicity (83.15%) against MCF-7 cell line, and it was partially comparable with the cytotoxicity activity (91.35%) of positive control (Doxorubicin). These findings indicate that plant-mediated AgNPs have significant antioxidant and anticancer activity, and thus may be considered for biomedical applications pending the results of some in vivo experiments.