10 Gram-scale synthesis of TY-Phos ligand and its application in carbene insertion of Si-H bonds. (28th September 2022)

• Record Type: Journal Article
• Authors: Zhang, Yaochen; Pan, Zhangjin; Guo, Hao; Yang, Junfeng; Zhang, Junliang
• Is Part Of: Tetrahedron letters. Volume 107(2022)
• Publication Date: 2022-09-28
• Subjects: Sadphos -- TY-Phos -- Asymmetric catalysis -- Chiral ligand -- Carbene insertion; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154120
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: The design of chiral ligands has always been one of the most prominent research areas in asymmetric catalysis. This method reports on the 10 g-scale synthesis of one class of Sadphos: TY-Phos ligand. The ligand preparation could be carried out on a scale of 10 g with a reasonable yield, and the preliminary exploration of its application in the enantioselective insertion of carbenes into Si−H bonds is reported.