Barrigenol-like triterpenoid saponins from the husks of Xanthoceras sorbifolia bunge and their anti-inflammatory activity by inhibiting COX-2 and iNOS expression. (December 2022)

• Record Type: Journal Article
• Authors: Zhao, Jiaming; Xu, Jixuan; Zhang, Zhiqi; Shao, Zhutao; Meng, Dali
• Is Part Of: Phytochemistry. Volume 204(2022)
• Publication Date: 2022-12
• Subjects: Xanthoceras sorbifolia -- Sapindaceae -- Husks -- Barrigenol-type saponins -- Anti-inflammation -- NF-κB pathway -- COX-2 -- iNOS; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113430
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: The husks of Xanthoceras sorbifolia Bunge were explored resulting in the isolation of nine undescribed compounds and seven known compounds. Their structures were defined by NMR spectroscopic techniques, HRESIMS analyses and DP4+ possibility analysis. Three of them showed evident inhibition on NO productions in LPS-induced BV-2 cells by controlling the expression of the nuclear factor-kappa-B (NF- κ B) signaling pathway. Furthermore, they also markedly decreased the expression of the proteins COX-2 and iNOS. In addition, most compounds showed no cytotoxicity against Hep 3B, A549, HCT 116, AGS, MCF-7 cell lines. These findings showed that the husks of X. sorbifolia might have considerable potential for the prevention of inflammation-related neurodegenerative disorders. Graphical abstract: Three of nine undescribed barrigenol triterpenoid saponins showed evident inhibition on NO productions in LPS-induced BV-2 cells by controlling the expression of the nuclear factor-kappa-B (NF-κB) signaling pathway and decreasing the expression of the proteins COX-2 and iNOS. Image 1 Highlights: Nine undescribed triterpenoid saponins were gained from Xanthoceras sorbifolia. Two saponins contain a rare C-15 mono-oxygenation moiety or an ester group at C-28. Three showed evident inhibition effects of NO release by LPS-induced BV-2 cells. Their anti-inflammatory mechanism may be related to NF- κ B signaling pathway.