Poor morphology of inner cell mass increases birth weight and large for gestational age. Issue 5 (November 2022)

• Record Type: Journal Article
• Authors: Zhu, Jinliang; Lian, Ying; Zhuang, Xinjie; Lin, Shengli; Zheng, Xiaoying; Li, Junsheng; Li, Rong; Liu, Ping
• Is Part Of: Reproductive biomedicine online. Volume 45:Issue 5(2022)
• Page Start: 890
• Page End: 897
• Publication Date: 2022-11
• Subjects: Birthweight -- Large for gestational age -- Morphological grading -- Perinatal outcome -- Warmed blastocyst; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2022.06.025
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: Research question: Can inner cell mass (ICM) and trophectoderm morphological grading, especially ICM and trophectoderm graded C, affect perinatal outcomes? Design: A retrospective review of medical records of 8946 singletons delivered from vitrified–warmed single blastocyst transfer cycles between January 2009 and December 2020. Results: Inner cell mass graded C had a higher adjusted birth weight than ICM graded A (0.61 ± 1.06 versus 0.48 ± 1.06; P = 0.025). Large for gestational age (LGA) increased with decreasing ICM morphological grading (18.96%, 21.88% and 23.38%; grade B versus grade A, P = 0.013; grade C versus grade A, P = 0.036) ( P < 0.025 was considered statistically significant for multiple pairwise comparisons). Linear regression analysis suggested that ICM morphological grading was significantly associated with adjusted birth weight, with grade C increasing adjusted birth weight compared with grade A (β 0.13, 95% CI 0.00 to 0.25, P = 0.043) ( P < 0.05 was considered statistically significant for linear regression). Logistic regression analysis suggested that ICM morphological grading was significantly associated with LGA, with grade C increasing LGA compared with grade A (adjusted OR 1.37, 95% CI 1.03 to 1.81). Moreover, blastocysts with ICM graded C had a higher chance of being a male infant compared with ICM graded A (adjusted OR 1.32, 95% CI 1.04 to 1.68). Conclusions: Inner cell mass morphological grading was significantly associated with adjusted birth weight and LGA. Poor ICM graded C increased birth weight and LGA.