Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review. (1st January 2023)

• Record Type: Journal Article
• Authors: Zheng, Xueli; Wang, Botao; Tang, Xin; Mao, Bingyong; Zhang, Qiuxiang; Zhang, Tianmeng; Zhao, Jianxin; Cui, Shumao; Chen, Wei
• Is Part Of: Carbohydrate polymers. Volume 299(2023)
• Publication Date: 2023-01-01
• Subjects: HA Hyaluronic acid -- GlcA (β, 1–4)-glucuronic acid -- GlcNAc (β, 1–3)-N-acetylglucosamine -- HAS Hyaluronic acid synthase -- HYALs Hyaluronidases -- HMM-HA High molar mass-HA -- LMM-HA Low molar mass-HA -- oHA Oligosaccharide HA -- HARE HA endocytosis receptor -- RHAMM Receptor for HA-mediated motility -- LYVE-1 Lymphatic vessel endothelial hyaluronan receptor-1 -- ECM Extracellular matrix -- HYBID Hyaluronan Binding Protein Involved in hyaluronan Depolymerization -- UGDH UDP-glucose dehydrogenase -- NAGK GlcNAc kinase -- PGM3 Phosphoglucomutase 3 -- UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -- GFAT Glutamine-fructose-6-phosphate transaminase -- GNPDA Glucosamine-6-phosphate deaminases -- UGPase UDP-Glucose pyrophosphorylase -- AMDHD2 N-acetylglucosamine-6-phosphate deacetylase 2 -- G1P Glucose-1-phosphate -- F6P Fructose-6-phosphate -- TIMMPs Tissue inhibitors of metalloproteinases -- MMPs Matrix metalloproteinases -- IOP Intraocular Pressure -- DED Dry eye disease -- GAGs Glycosaminoglycans -- HBD2 Human β-defensin 2 -- TJ Tight junction -- NEC Necrotizing enterocolitis -- SOCS3 Suppressor of cytokine signaling 3 -- HYA Microbial hyaluronidase -- ABC ATP-binding cassette -- PTS Phosphotransferase system -- UGL Unsaturated glucuronic hydrolase -- T2DM Type 2 Diabetes Mellitus -- 99mTc-HA 99mTechnetium Labeling of HA -- 14C-HA 14C to label HA -- 125I-HA-Tm 125I labeled HA-tyramine conjugate -- GHs Glycoside hydrolases -- PLs Polysaccharide lyases; Hyaluronic acid -- Absorption -- Metabolism -- Health benefits -- Probiotics; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.120153
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content in tissues gradually decreases with age, causing age-related health problems. Exogenous HA supplements are used to prevent or treat these problems including skin dryness and wrinkles, intestinal imbalance, xerophthalmia, and arthritis after absorption. Moreover, some probiotics are able to promote endogenous HA synthesis and alleviate symptoms caused by HA loss, thus introducing potential preventative or therapeutic applications of HA and probiotics. Here, we review the oral absorption, metabolism, and biological function of HA as well as the potential role of probiotics and HA in increasing the efficacy of HA supplements. Graphical abstract: Unlabelled Image