Deep-spindle: An automated sleep spindle detection system for analysis of infant sleep spindles. (November 2022)

• Record Type: Journal Article
• Authors: Wei, Lan; Ventura, Soraia; Ryan, Mary Anne; Mathieson, Sean; Boylan, Geraldine B.; Lowery, Madeleine; Mooney, Catherine
• Is Part Of: Computers in biology and medicine. Volume 150(2022)
• Publication Date: 2022-11
• Subjects: Deep learning -- EEG -- Sleep spindles -- Ex-term and ex-preterm infant -- Automatic detection system; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2022.106096
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Background: Sleep spindles are an indicator of the development and integrity of the central nervous system in infants. Identifying sleep spindles manually in EEG is time-consuming and typically requires experienced experts. Automated detection of sleep spindles would greatly facilitate this analysis. Deep learning methods have been widely used recently in EEG analysis. Method: We have developed a deep learning-based automated sleep spindle detection system, Deep-spindle, which employs a convolutional neural network (CNN) combined with a bidirectional Long Short-Term Memory (LSTM) network, which could assist in the analysis of infant sleep spindles. Deep-spindle was trained on the EEGs of ex-term infants to estimate the number and duration of sleep spindles. The ex-term EEG on channel F4-C4 was split into training (N=81) and validation (N=30) sets. An additional 30 ex-term EEG and 54 ex-preterm infant EEGs (channel F4-C4 and F3-C3) were used as an independent test set. Result: Deep-spindle detected the number of sleep spindles with 91.9% to 96.5% sensitivity and 95.3% to 96.7% specificity, and estimated sleep spindle duration with a percent error of 13.1% to 19.1% in the independent test set. For each detected spindle event, the user is presented with amplitude, power spectral density and the spectrogram of the corresponding spindle EEG, and the probability of the event being a sleep spindle event, providing the user with insight into why the event is predicted as a sleep spindle to provide confidence in the predictions. Conclusion: The Deep-spindle system can reduce physicians' workload, demonstrating the potential to assist physicians in the automated analysis of sleep spindles in infants. Graphical abstract: Highlights: Deep-spindle will allow a faster and more reliable infant sleep spindles detection. Deep-spindle can estimate both the number and duration of sleep spindles in infants. Deep-spindle can visualise the detected sleep spindle event to gain users' trust.