Detection of macrophages engulfing cholesterol crystals and docosahexaenoic acid from spontaneous ruptured aortic plaque. Issue 5 (November 2022)

• Record Type: Journal Article
• Authors: Noda, Hirotaka; Yutani, Chikao; Zaima, Nobuhiro; Komatsu, Sei; Iwa, Nobuzo; Takahashi, Satoru; Takewa, Mitsuhiko; Ohara, Tomoki; Kodama, Kazuhisa
• Is Part Of: Journal of cardiology cases. Volume 26:Issue 5(2022)
• Page Start: 364
• Page End: 366
• Publication Date: 2022-11
• Subjects: Cholesterol crystals -- Imaging mass spectrometry -- Spontaneous rupture aortic plaque -- Angioscopy -- Docosahexaenoic acid; Cardiology -- Periodicals; Cardiovascular Diseases -- Case Reports; Cardiovascular Diseases -- Periodicals; Cardiology -- Case Reports; Cardiology -- Periodicals; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.jccase.2022.08.001
• Languages: English
• ISSNs: 1878-5409

Abstract

Abstract: We visualized macrophages engulfing cholesterol crystals from spontaneously ruptured aortic plaques sampled by angioscopy. Docosahexaenoic acid cholesterol ester (DHA-CE) was demonstrated by imaging mass spectrometry. DHA-CE is reported to be produced by macrophages against inflammation. Activities of macrophages against atherosclerosis inside plaques was shown from spontaneously ruptured aortic plaques in situ . Learning objectives: Activities of macrophages such as engulfing cholesterol crystals and producing docosahexaenoic acid cholesterol ester were shown from spontaneously ruptured aortic plaques in situ .