Limonoids with anti-inflammatory activity: A review. (December 2022)

• Record Type: Journal Article
• Authors: Hilmayanti, Erina; Nurlelasari, ; Supratman, Unang; Kabayama, Kazuya; Shimoyama, Atsushi; Fukase, Koichi
• Is Part Of: Phytochemistry. Volume 204(2022)
• Publication Date: 2022-12
• Subjects: Anti-inflammatory activity -- Limonoid -- Meliaceae -- Rutaceae -- Content list; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113469
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: The natural limonoids distributed mainly in the Meliaceae and Rutaceae plants are known for their unique and complex structure with high degree oxidation and cyclic rearrangement. However, these compounds exhibit a broad range of biological activities such as insecticidal, antibacterial, antifungal, antimalarial, antioxidant, anticancer, antiviral, and anti-inflammatory. There is still limited report about the biological activity of the anti-inflammatory effect of limonoids isolated from plants. Therefore, this study aimed to examine the effect of intact, deformed and rearranged limonoids as anti-inflammatory agents. The majority of anti-inflammatory investigations were evaluated by in vitro and in vivo assays of the isolated pure compounds and their derivatives. For the in vitro study, intact and C-ring seco limonoids showed a potent inhibitory effect against NO production. The in vivo analysis of Intact, C-seco, and AD-seco limonoids showed a potent effect based on the inhibition of pro-inflammatory cytokines expression, indicating their potency as anti-inflammatory agents. Graphical abstract: Image 1 Highlights: The structure and anti-inflammatory limonoids have been discussed. The in-vitro study, intact and C-ring seco limonoids showed a potent inhibitory effect against NO production. The in-vivo study of intact, C-seco, and AD-seco limonoids showed a potent effect for inhibition of pro-inflammatory cytokines expression.