Bistrochelides H−L: Biscembranoids from the south China sea soft coral Sarcophyton serenei. (December 2022)

• Record Type: Journal Article
• Authors: Yan, Xia; Liu, Jing; Huang, Jian; Wang, Yiji; Leng, Xue; Li, Te; Ouyang, Han; Yan, Xiaojun; He, Shan
• Is Part Of: Phytochemistry. Volume 204(2022)
• Publication Date: 2022-12
• Subjects: Sarcophyton serenei -- Alcyoniidae -- Soft coral -- Biological activity -- Biscembranoids; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113438
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Five undescribed biscembranoids, bistrochelides H−L, along with four known biscembranoids, glaucumolides A−B and bistrochelides A−B, were isolated from the soft coral Sarcophyton serenei collected off the Xisha Island in the South China Sea. The structures of these compounds were elucidated by HRESIMS (high-resolution electrospray ionization mass spectroscopy) spectrometry, NMR (nuclear magnetic resonance) spectroscopy, X-ray diffraction analysis, electronic circular dichroism (ECD), and the comparison of their spectroscopic data with those reported in the literature. In bioassay, some compounds showed a strong inhibitory effect on osteoclast precursor cells at the concentration of 10 μM. Additionally, all compounds exhibited weakly antimicrobial activity against Vibrio harveyi . Graphical abstract: Image 1 Highlights: Five undescribed biscembranoids were isolated from soft coral Sarcophyton serenei. The configurations of bistrochelide H was elucidated by X-ray diffraction analysis. Some compounds showed strong inhibitory effect of osteoclast precursor cell.