Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell tumours. (20th December 2022)

• Record Type: Journal Article
• Authors: Rinaldi, Valentina; Boari, Andrea; Ressel, Lorenzo; Bongiovanni, Laura; Crisi, Paolo Emidio; Cabibbo, Emanuele; Finotello, Riccardo
• Is Part Of: Research in veterinary science. Volume 152(2022)
• Page Start: 530
• Page End: 536
• Publication Date: 2022-12-20
• Subjects: Cannabinoid -- Dog -- Mast cell tumor -- Histopathology -- Immunohistochemistry; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2022.09.013
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: Cannabinoid receptors (CB1 and CB2) belong to endocannabinoid system (ECS), which is also composed from endocannabinoids and the enzymatic systems involved in their biosynthesis and degradation. The expression of CB1 and CB2 have been previously identified in normal canine mast cell and in atopic dermatitis. Canine cutaneous mast cell tumours (cMCTs) are among the most common cutaneous neoplasms in dogs and have a highly variable clinical behaviour. Expression of CB1-CB2 was assessed by means of immunohistochemistry in thirty-seven dogs (from 2019 to 2021) with proven histological diagnosis of cMCT. Dogs were divided in two groups according to the Kiupel's grading system: high-grade (HG) cMCT and low-grade (LG) cMCT. A semiquantitative (score 0–3) and quantitative assessment of immunoreactivity (IR) was performed for each case. Our results show that there CB1 and CB2 are highly expressed in LG- cMCT, in contrast to HG- cMCT. Highlights: This is the first study focusing on the expression of cannabinoid receptors in spontaneous canine mast cell tumours. Canine cutaneous mast cell tumours (cMCT) express cannabinoid receptors CB1 and CB2 Low-Grade Kiupel cMCT have a high immunoreactivity for CB1 and CB2 Immunoreactivity of CB1 and CB2 is inversely correlated with Kiupel histological grade