Colloidal Jamming by Interfacial Self‐Assembled Polymers: A Robust Route for Ultrahigh Efficient Encapsulation. Issue 43 (26th September 2022)

• Record Type: Journal Article
• Authors: Huo, Qingqing; Gao, Yue; Wu, Wenbo; Hu, Shuai; Zhang, Zifan; Li, Zhi; Tian, Yuling; Quan, Peng; Li, Wen; Liu, Dongfei
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 43(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-26
• Subjects: Colloids -- Encapsulation -- Interface Jamming -- Interfacial Self-Assembly -- Phase-Transfer; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202208738
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The control of cargo phase‐transfer is of interest for many applications in science and technology. Herein, we report a simple, versatile and robust method to block the phase‐transfer of cargo colloids by interfacial self‐assembled amphiphilic polymer molecules. After simply increasing the concentration of amphiphilic polymers, the orientation of interfacial polymer molecules changed from flat to upright, forming a thick three‐dimensional polymer layer at the oil‐water interface. Even under fierce external force, this thick interfacial layer robustly prevented the phase‐transfer of cargo colloids, resulting in an ultrahigh encapsulation efficiency (up to 97.1 %) for proteins and peptides. One single injection of high insulin‐loaded microcomposites (58.3 wt%) kept the blood glucose level within the normoglycemic state for 10 days in type 1 diabetic rats. The mass of administrated amphiphilic polymers was 1889 times smaller than that of microcomposites prepared with non‐amphiphilic ones. Abstract : Interfacial self‐assembly of amphiphilic polymers blocks the phase‐transfer of cargo colloids giving an efficient protein and peptide encapsulation. Profiting from the high mass fraction of therapeutics (58.3 wt%), the mass of administrated amphiphilic polymers was 1889 times lower than that with non‐amphiphilic ones. One injection of high insulin‐loaded microcomposites held the blood glucose level within normoglycemic state for 10 days.