Gut Microbiota in Monozygotic Twins Discordant for Parkinson's Disease. Issue 4 (4th August 2022)

• Record Type: Journal Article
• Authors: Bolliri, Carlotta; Fontana, Alessandra; Cereda, Emanuele; Barichella, Michela; Cilia, Roberto; Ferri, Valentina; Caronni, Serena; Calandrella, Daniela; Morelli, Lorenzo; Pezzoli, Gianni
• Is Part Of: Annals of neurology. Volume 92:Issue 4(2022)
• Page Start: 631
• Page End: 636
• Publication Date: 2022-08-04
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.26454
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : Differences in gut microbiota between Parkinson's disease patients and controls seem to depend on multiple—frequently unmeasured—confounders. Monozygotic twins offer a unique model for controlling several factors responsible for interpersonal variation in gut microbiota. Fecal samples from 20 monozygotic twin pairs (n = 40) discordant for Parkinson's disease were studied (metagenomic shotgun analysis). Paired data analysis detected minimal differences in bacterial taxa abundance at species level ( Bacteroides pectinophilus [ p = 0.037], Bifidobacterium pseudocatenulatum [ p = 0.050], and Bifidobacterium catenulatum [ p = 0.025]) and in predicted metabolic pathways ( primary bile acid biosynthesis [ p = 0.037]). Additional studies are warranted to understand the role of gut microbiota in the pathogenesis of Parkinson's disease. ANN NEUROL 2022;92:631–636