Recent Advances in Cyanobacterial Biotransformations. Issue 11 (16th September 2022)

• Record Type: Journal Article
• Authors: Malihan‐Yap, Lenny; Grimm, Hanna C.; Kourist, Robert
• Other Names: Beller Matthias guestEditor.; Bender Michael guestEditor.; Bornscheuer Uwe T. guestEditor.; Schunk Stephan guestEditor.
• Is Part Of: Chemie Ingenieur Technik. Volume 94:Issue 11(2022)
• Page Start: 1628
• Page End: 1644
• Publication Date: 2022-09-16
• Subjects: Biocatalysis -- Biotransformations -- Cyanobacteria -- Photosynthesis; Chemical engineering -- Patents -- Periodicals; Chemical engineering -- Periodicals; Chemical industry -- Periodicals; Chemistry, Technical -- Periodicals; 660.05
• DOI: 10.1002/cite.202200077
• Languages: English
• ISSNs: 0009-286X

Abstract

Abstract: Light‐driven biotransformations in recombinant cyanobacteria have been explored in recent years for the production of chiral compounds and platform chemicals. In particular, cyanobacteria harboring oxidoreductases proved to be sustainable hosts providing and recycling reducing equivalents and improving the atom economy of the reactions. However, the provision of light in photobioreactors is considered to be the major bottleneck for up‐scaling. In this review, genetic tools for generating recombinant cyanobacterial strains and up to date cyanobacterial biotransformations including redesigning of the photosynthetic electron transport chain to increase specific activities are presented. Finally, several photobioreactor geometries to circumvent the light limitation are discussed and some future perspectives are presented. Abstract : The generation of recombinant cyanobacteria is performed using genetic tools and their activities are increased by enzyme discovery as well as redesigning of the photosynthetic electron transport chain. Various photobioreactors are utilized to upscale the reaction and overcome light limitation.