Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris. Issue 10 (6th September 2022)

• Record Type: Journal Article
• Authors: Hyung Koo, Man; Shin, Min‐Ji; Ju Kim, Min; Lee, Seulah; Eun So, Jae; Hee Kim, Ji; Hyuck Lee, Jun; Suh, Sung‐Suk; Joung Youn, Ui
• Is Part Of: Chemistry & biodiversity. Volume 19:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-06
• Subjects: Himantormia lugubris -- depsidone -- antimicrobial -- cytotoxicity -- lichen; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202200374
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Two new depsidones, himantormiones A and B (1 and 2 ) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds (3–9 ). The structures of two new compounds (1 and 2 ) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR‐MS. The isolated compounds were tested for antimicrobial and cytotoxic activities, where himantormione B (2 ) exhibited inhibitory effect against Staphylococcus aureus with the IC50 value of 7.01±0.85 mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC50 value of 1.11±0.85 μM, where that of the positive control, 5‐fluouracil, was 9.4±1.90 μM. Abstract :